F1RefidQuick AuthorAuthorTitlePublication DatePeriodicalF8VolumeF10IssueF12Page Start-EndGroupF15Publication DataConditionCondition (to hide)Outcome Measurescleaned up resultsOutcome Measures_Total ParticipantsQuality Assignment (SIGN 50)AbstractKeywordsPowerPower1Provider TypeIntervention Description: Number Assigned (Dropout Rate)# Assigned (Dropout Rate)_double check # assignIntervention Description: DosagesIntervention Description: Dosages1*Meta-AnalysisRelevant Results _ConclusionsAdverse EventsPubMed Link
4 675 Collinge, 2013* W. Collinge, J. Kahn, T. Walton, L. Kozak, S. Bauer-Wu, K. Fletcher, P. Yarnold and R. Soltysik Touch, Caring, and Cancer: randomized controlled trial of a multimedia caregiver education program 2013 Support Care Cancer vol 21 vol 21 5 pages 1405-14 Cancer pages 1405-14 Support Care Cancer, vol 21: 5, pages 1405-14 Cancer: Cancer dyads 97c cancer dyads (mean age = 53 ± 12.6) Numerical Rating Scale (pain) Numerical Rating Scale (fatigue) Numerical Rating Scale (stress/anxiety) Numerical Rating Scale (depression) Perceived Stress Scale (stress) Attitudes toward caregiving Caregiver Reaction Assessment (caregiver esteem) Functional Assessment of Cancer Therapy-General (physical, functional, social/family, and emotional adjustment) Pain: Numerical Rating Scale; Sleep: Numerical Rating Scale; Mood: Numerical Rating Scale; Stress: Perceived Stress Scale (stress) Quality of Life: Functional Assessment of Cancer Therapy-General, Attitudes toward caregiving, Caregiver Reaction Assessm 97 2-Acceptable PURPOSE: A randomized controlled trial was conducted to evaluate outcomes of a multimedia instructional program for family caregivers in simple touch-based techniques to provide comfort to cancer patients at home. METHODS: A multilingual 78-min DVD and 66-page manual were produced for home-based instruction. Content addresses attitudes and communication about touch in cancer psychological preparation for giving and receiving touch safety precautions massage techniques for comfort and relaxation acupressure for specific cancer-related symptoms and practice in the home setting. Materials were produced in English Spanish and Chinese versions. A community-based multiethnic sample of 97 adult patient/caregiver dyads was randomized to experimental (massage) or attention control (reading) groups for 4 weeks. Massage dyads received the program and instructions to practice at least three times per week while control caregivers read to their patients for the same frequency. Self-report instruments assessed change in symptom severity quality of life perceived stress and caregiver attitudes. RESULTS: Significant reductions in all symptoms occurred for patients after both activities: 12-28 % reductions after reading vs. 29-44 % after massage. Massage caregivers showed significant gains in confidence comfort and self-efficacy using touch and massage as forms of caregiving. CONCLUSIONS: Multimedia instruction in touch and massage methods may offer family members a viable means of enhancing self-efficacy and satisfaction in caregiving while decreasing patient pain depression and other symptoms. Family members may be able to learn and apply safe and simple methods that increase patient comfort and reduce distress. Adolescent Not Described ND Caregiver Massage: 47(4%); Reading (Active Control): 50 (0%). 47(4%); 50 (0%). Massage: ND x 5-20 mins, 3x/w, 4w + ND; Reading (Active Control): ND x 5-20 mins, 3x/w, 4w + ND. ND x 5-20 mins, 3x/w, 4w + ND; ND x 5-20 mins, 3x/w, 4w + ND. Yes *Numerical Rating Scale (pain): p < 0.05 (within groups) (Massage) at 3w and 4w; p = Not Significant (within groups) (Active Control) at all time points, Effect Size = 0.62, Active Control, pre / post; *Numerical Rating Scale (fatigue): p < 0.05 (within groups) (Massage) at 1w and 4w; p = Not Significant (within groups) (Active Control) at all time points, Effect Size = -0.30, Active Control, pre / post; *Numerical Rating Scale (stress/anxiety): p < 0.05 (within groups) (Massage) at 2, 3 and 4w; p = Not Significant (within groups) (Active Control) at all time points, Effect Size = -0.35, Active Control, pre / post; Numerical Rating Scale (depression): p = Not Significant (within groups) (both groups) at all time points; Perceived Stress Scale (stress): p = Not Significant (within groups) (both groups) at 1 mos; p = Not Significant (between groups) at 1 mos; Attitudes toward caregiving: p < 0.05 (within groups) (both groups) at FU; Caregiver Reaction Assessment (caregiver esteem): p = Not Significant (within groups) (both groups) at FU; p = Not Significant (between groups) at FU; Functional Assessment of Cancer Therapy-General (physical, functional, social/family, and emotional adjustment): p = Not Significant (within groups) (both groups) at 1 mos; p = Not Significant (between groups) at 1 mos. Massage effective for: Pain, Sleep, Stress, Mood, Quality of Life. Authors report NO AEs occurred http://www.ncbi.nlm.nih.gov/pubmed/?term=collinge+Touch%2C+Caring%2C+and+Cancer%3A+randomized+controlled+trial+of+a+multimedia+caregiver+education+prograhttp://www.ncbi.nlm.nih.gov/pubmed/?term=collinge+Touch%2C+Caring%2C+and+Cancer%3A+randomized+controll
F1 4
Refid 675
Quick Author Collinge, 2013*
Author W. Collinge, J. Kahn, T. Walton, L. Kozak, S. Bauer-Wu, K. Fletcher, P. Yarnold and R. Soltysik
Title Touch, Caring, and Cancer: randomized controlled trial of a multimedia caregiver education program
Publication Date 2013
Periodical Support Care Cancer
F8 vol
Volume 21
F10 vol 21
Issue 5
F12 pages
Page Start-End 1405-14
Group Cancer
F15 pages 1405-14
Publication Data Support Care Cancer, vol 21: 5, pages 1405-14
Condition Cancer: Cancer dyads
Condition (to hide) 97c cancer dyads (mean age = 53 ± 12.6)
Outcome Measures
cleaned up results Numerical Rating Scale (pain) Numerical Rating Scale (fatigue) Numerical Rating Scale (stress/anxiety) Numerical Rating Scale (depression) Perceived Stress Scale (stress) Attitudes toward caregiving Caregiver Reaction Assessment (caregiver esteem) Functional Assessment of Cancer Therapy-General (physical, functional, social/family, and emotional adjustment)
Outcome Measures_ Pain: Numerical Rating Scale; Sleep: Numerical Rating Scale; Mood: Numerical Rating Scale; Stress: Perceived Stress Scale (stress) Quality of Life: Functional Assessment of Cancer Therapy-General, Attitudes toward caregiving, Caregiver Reaction Assessm
Total Participants 97
Quality Assignment (SIGN 50) 2-Acceptable
Abstract PURPOSE: A randomized controlled trial was conducted to evaluate outcomes of a multimedia instructional program for family caregivers in simple touch-based techniques to provide comfort to cancer patients at home. METHODS: A multilingual 78-min DVD and 66-page manual were produced for home-based instruction. Content addresses attitudes and communication about touch in cancer psychological preparation for giving and receiving touch safety precautions massage techniques for comfort and relaxation acupressure for specific cancer-related symptoms and practice in the home setting. Materials were produced in English Spanish and Chinese versions. A community-based multiethnic sample of 97 adult patient/caregiver dyads was randomized to experimental (massage) or attention control (reading) groups for 4 weeks. Massage dyads received the program and instructions to practice at least three times per week while control caregivers read to their patients for the same frequency. Self-report instruments assessed change in symptom severity quality of life perceived stress and caregiver attitudes. RESULTS: Significant reductions in all symptoms occurred for patients after both activities: 12-28 % reductions after reading vs. 29-44 % after massage. Massage caregivers showed significant gains in confidence comfort and self-efficacy using touch and massage as forms of caregiving. CONCLUSIONS: Multimedia instruction in touch and massage methods may offer family members a viable means of enhancing self-efficacy and satisfaction in caregiving while decreasing patient pain depression and other symptoms. Family members may be able to learn and apply safe and simple methods that increase patient comfort and reduce distress.
Keywords Adolescent
Power Not Described
Power1 ND
Provider Type Caregiver
Intervention Description: Number Assigned (Dropout Rate) Massage: 47(4%); Reading (Active Control): 50 (0%).
# Assigned (Dropout Rate)_ 47(4%); 50 (0%).
double check # assign
Intervention Description: Dosages Massage: ND x 5-20 mins, 3x/w, 4w + ND; Reading (Active Control): ND x 5-20 mins, 3x/w, 4w + ND.
Intervention Description: Dosages1 ND x 5-20 mins, 3x/w, 4w + ND; ND x 5-20 mins, 3x/w, 4w + ND.
*Meta-Analysis Yes
Relevant Results _ *Numerical Rating Scale (pain): p < 0.05 (within groups) (Massage) at 3w and 4w; p = Not Significant (within groups) (Active Control) at all time points, Effect Size = 0.62, Active Control, pre / post; *Numerical Rating Scale (fatigue): p < 0.05 (within groups) (Massage) at 1w and 4w; p = Not Significant (within groups) (Active Control) at all time points, Effect Size = -0.30, Active Control, pre / post; *Numerical Rating Scale (stress/anxiety): p < 0.05 (within groups) (Massage) at 2, 3 and 4w; p = Not Significant (within groups) (Active Control) at all time points, Effect Size = -0.35, Active Control, pre / post; Numerical Rating Scale (depression): p = Not Significant (within groups) (both groups) at all time points; Perceived Stress Scale (stress): p = Not Significant (within groups) (both groups) at 1 mos; p = Not Significant (between groups) at 1 mos; Attitudes toward caregiving: p < 0.05 (within groups) (both groups) at FU; Caregiver Reaction Assessment (caregiver esteem): p = Not Significant (within groups) (both groups) at FU; p = Not Significant (between groups) at FU; Functional Assessment of Cancer Therapy-General (physical, functional, social/family, and emotional adjustment): p = Not Significant (within groups) (both groups) at 1 mos; p = Not Significant (between groups) at 1 mos.
Conclusions Massage effective for: Pain, Sleep, Stress, Mood, Quality of Life.
Adverse Events Authors report NO AEs occurred
PubMed Link http://www.ncbi.nlm.nih.gov/pubmed/?term=collinge+Touch%2C+Caring%2C+and+Cancer%3A+randomized+controlled+trial+of+a+multimedia+caregiver+education+prograhttp://www.ncbi.nlm.nih.gov/pubmed/?term=collinge+Touch%2C+Caring%2C+and+Cancer%3A+randomized+controll
5 1594 Jane, 2011* S. W. Jane, S. L. Chen, D. J. Wilkie, Y. C. Lin, S. W. Foreman, R. D. Beaton, J. Y. Fan, M. Y. Lu, Y. Y. Wang, Y. H. Lin and M. N. Liao Effects of massage on pain, mood status, relaxation, and sleep in Taiwanese patients with metastatic bone pain: a randomized clinical trial 2011 Pain vol 152 vol 152 10 pages 2432-42 Cancer pages 2432-42 Pain, vol 152: 10, pages 2432-42 Cancer: Metastatic cancer patients 72ac (30 M/42 F) metastatic cancer patients (mean age = 50 ± 10.6) Visual Analog Scale (present pain intensity) Visual Analog Scale (muscle relaxation) Visual Analog Scale (sleep) Visual Analog Scale (mood) Symptom Distress Scale (distress symptoms) Pain: Visual Analog Scale; Sleep: Visual Analog Scale; Mood: Visual Analog Scale; Stress: Symptom Distress Scale; 72 1-High To date patients with bony metastases were only a small fraction of the samples studied or they were entirely excluded. Patients with metastatic cancers such as bone metastases are more likely to report pain compared to patients without metastatic cancer (50-74% and 15% respectively). Their cancer pain results in substantial morbidity and disrupted quality of life in 34-45% of cancer patients. Massage therapy (MT) appears to have positive effects in patients with cancer; however the benefits of MT specifically in patients with metastatic bone pain remains unknown. The purpose of this randomized clinical trial was to compare the efficacy of MT to a social attention control condition on pain intensity mood status muscle relaxation and sleep quality in a sample (n=72) of Taiwanese cancer patients with bone metastases. In this investigation MT was shown to have beneficial within- or between-subjects effects on pain mood muscle relaxation and sleep quality. Results from repeated-measures analysis of covariance demonstrated that massage resulted in a linear trend of improvements in mood and relaxation over time. More importantly the reduction in pain with massage was both statistically and clinically significant and the massage-related effects on relaxation were sustained for at least 16-18 hours postintervention. Furthermore massage-related effects on sleep were associated with within-subjects effects. Future studies are suggested with increased sample sizes a longer interventional period duration and an objective and sensitive measure of sleep. Overall results from this study support employing MT as an adjuvant to other therapies in improving bone pain management. Adult Yes, power achieved Yes, To achieve power of at least 95% likelihood of detecting clinically meaningful differences between groups, we estimated needed enrollment at 72, assuming 15% attrition rate and a correlation of 0.5 among assessment Nurse Massage Therapy: 36 (6%); Social Attention (Active Control): 36 (8%). 36 (6%); 36 (8%). Massage Therapy: 3 x 40 mins, daily, 3d + ND; Social Attention (Active Control): 3 x 45 mins, 1x, 3d + ND. 3 x 40 mins, daily, 3d + ND; 3 x 45 mins, 1x, 3d + ND. Yes *Visual Analog Scale (present pain intensity): p < 0.01d (Massage Therapy), p = Not Significant (within groups) (Active Control) at all time points; p < 0.01e at all time points, Effect Size = -0.92, Active Control, pre / post; Visual Analog Scale (muscle relaxation): p = Not Significant (within groups) (both groups) at post; p = Not Significant (between groups) at post; Visual Analog Scale (sleep): p = Not Significant (within groups) (both groups) at post, p = Not Significant (between groups) at all time points; Visual Analog Scale (mood): p < 0.03 (within groups) (Massage Therapy), p = Not Significant (within groups) (Active Control) at all time points; p = Not Significant (between groups) at post; Symptom Distress Scale (distress symptoms): p = Not Described. Massage effective for: Pain, Mood. Authors report NO AEs occurred http://www.ncbi.nlm.nih.gov/pubmed/?term=Effects+of+massage+on+pain%2C+mood+status%2C+relaxation%2C+and+sleep+in+Taiwanese+patients+with+metastatic+bone+pain%3A+a+randomized+clinical+trial
F1 5
Refid 1594
Quick Author Jane, 2011*
Author S. W. Jane, S. L. Chen, D. J. Wilkie, Y. C. Lin, S. W. Foreman, R. D. Beaton, J. Y. Fan, M. Y. Lu, Y. Y. Wang, Y. H. Lin and M. N. Liao
Title Effects of massage on pain, mood status, relaxation, and sleep in Taiwanese patients with metastatic bone pain: a randomized clinical trial
Publication Date 2011
Periodical Pain
F8 vol
Volume 152
F10 vol 152
Issue 10
F12 pages
Page Start-End 2432-42
Group Cancer
F15 pages 2432-42
Publication Data Pain, vol 152: 10, pages 2432-42
Condition Cancer: Metastatic cancer patients
Condition (to hide) 72ac (30 M/42 F) metastatic cancer patients (mean age = 50 ± 10.6)
Outcome Measures
cleaned up results Visual Analog Scale (present pain intensity) Visual Analog Scale (muscle relaxation) Visual Analog Scale (sleep) Visual Analog Scale (mood) Symptom Distress Scale (distress symptoms)
Outcome Measures_ Pain: Visual Analog Scale; Sleep: Visual Analog Scale; Mood: Visual Analog Scale; Stress: Symptom Distress Scale;
Total Participants 72
Quality Assignment (SIGN 50) 1-High
Abstract To date patients with bony metastases were only a small fraction of the samples studied or they were entirely excluded. Patients with metastatic cancers such as bone metastases are more likely to report pain compared to patients without metastatic cancer (50-74% and 15% respectively). Their cancer pain results in substantial morbidity and disrupted quality of life in 34-45% of cancer patients. Massage therapy (MT) appears to have positive effects in patients with cancer; however the benefits of MT specifically in patients with metastatic bone pain remains unknown. The purpose of this randomized clinical trial was to compare the efficacy of MT to a social attention control condition on pain intensity mood status muscle relaxation and sleep quality in a sample (n=72) of Taiwanese cancer patients with bone metastases. In this investigation MT was shown to have beneficial within- or between-subjects effects on pain mood muscle relaxation and sleep quality. Results from repeated-measures analysis of covariance demonstrated that massage resulted in a linear trend of improvements in mood and relaxation over time. More importantly the reduction in pain with massage was both statistically and clinically significant and the massage-related effects on relaxation were sustained for at least 16-18 hours postintervention. Furthermore massage-related effects on sleep were associated with within-subjects effects. Future studies are suggested with increased sample sizes a longer interventional period duration and an objective and sensitive measure of sleep. Overall results from this study support employing MT as an adjuvant to other therapies in improving bone pain management.
Keywords Adult
Power Yes, power achieved
Power1 Yes, To achieve power of at least 95% likelihood of detecting clinically meaningful differences between groups, we estimated needed enrollment at 72, assuming 15% attrition rate and a correlation of 0.5 among assessment
Provider Type Nurse
Intervention Description: Number Assigned (Dropout Rate) Massage Therapy: 36 (6%); Social Attention (Active Control): 36 (8%).
# Assigned (Dropout Rate)_ 36 (6%); 36 (8%).
double check # assign
Intervention Description: Dosages Massage Therapy: 3 x 40 mins, daily, 3d + ND; Social Attention (Active Control): 3 x 45 mins, 1x, 3d + ND.
Intervention Description: Dosages1 3 x 40 mins, daily, 3d + ND; 3 x 45 mins, 1x, 3d + ND.
*Meta-Analysis Yes
Relevant Results _ *Visual Analog Scale (present pain intensity): p < 0.01d (Massage Therapy), p = Not Significant (within groups) (Active Control) at all time points; p < 0.01e at all time points, Effect Size = -0.92, Active Control, pre / post; Visual Analog Scale (muscle relaxation): p = Not Significant (within groups) (both groups) at post; p = Not Significant (between groups) at post; Visual Analog Scale (sleep): p = Not Significant (within groups) (both groups) at post, p = Not Significant (between groups) at all time points; Visual Analog Scale (mood): p < 0.03 (within groups) (Massage Therapy), p = Not Significant (within groups) (Active Control) at all time points; p = Not Significant (between groups) at post; Symptom Distress Scale (distress symptoms): p = Not Described.
Conclusions Massage effective for: Pain, Mood.
Adverse Events Authors report NO AEs occurred
PubMed Link http://www.ncbi.nlm.nih.gov/pubmed/?term=Effects+of+massage+on+pain%2C+mood+status%2C+relaxation%2C+and+sleep+in+Taiwanese+patients+with+metastatic+bone+pain%3A+a+randomized+clinical+trial
6 1751 Khiewkhern, 2013 S. Khiewkhern, S. Promthet, A. Sukprasert, W. Eunhpinitpong and P. Bradshaw Effectiveness of aromatherapy with light thai massage for cellular immunity improvement in colorectal cancer patients receiving chemotherapy 2013 Asian Pac J Cancer Prev vol 14 vol 14 6 pages 3903-7 Cancer pages 3903-7 Asian Pac J Cancer Prev, vol 14: 6, pages 3903-7 Cancer: Colon cancer 66c (41 M/ 25 F) colorectal cancer patients (mean age = 59 ± 1.6) Numerical Rating Scale (pain) Numerical Rating Scale (fatigue) Numerical Rating Scale (stress or anxiety) Numerical Rating Scale (depression) Numerical Rating Scale (presenting symptom) White Blood Count Lymphocytes CD4 cells CD8 cells Pain: Numerical Rating Scale; Sleep: Numerical Rating Scale; Stress: Numerical Rating Scale; Mood: Numerical Rating Scale; Quality of Life: Numerical Rating Scale; Physiological: White Blood Count, Lymphocytes, CD4 cells, CD8 cells. 66 2-Acceptable BACKGROUND: Patients with colorectal cancer are usually treated with chemotherapy which reduces the number of blood cells especially white blood cells and consequently increases the risk of infections. Some research studies have reported that aromatherapy massage affects the immune system and improves immune function by for example increasing the numbers of natural killer cells and peripheral blood lymphocytes. However there has been no report of any study which provided good evidence as to whether aromatherapy with Thai massage could improve the immune system in patients with colorectal cancer. The objectives of this study were to determine whether the use of aromatherapy with light Thai massage in patients with colorectal cancer who have received chemotherapy can result in improvement of the cellular immunity and reduce the severity of the common symptoms of side effects. MATERIALS AND METHODS: Sixty-six patients with colorectal cancer in Phichit Hospital Thailand were enrolled in a single-blind randomised-controlled trial. The intervention consisted of three massage sessions with ginger and coconut oil over a 1-week period. The control group received standard supportive care only. Assessments were conducted at pre-assessment and at the end of one week of massage or standard care. Changes from pre-assessment to the end of treatment were measured in terms of white blood cells neutrophils lymphocytes CD4 and CD8 cells and the CD4/CD8 ratio and also the severity of self-rated symptom scores. RESULTS: The main finding was that after adjusting for pre-assessment values the mean lymphocyte count at the post-assessment was significantly higher (P=0.04) in the treatment group than in the controls. The size of this difference suggested that aromatherapy with Thai massage could boost lymphocyte numbers by 11%. The secondary outcomes were that at the post assessment the symptom severity scores for fatigue presenting symptom pain and stress were significantly lower in the massage group than in the standard care controls. CONCLUSIONS: Aromatherapy with light Thai massage can be beneficial for the immune systems of cancer patients who are undergoing chemotherapy by increasing the number of lymphocytes and can help to reduce the severity of common symptoms. Adult Not Described ND Therapist (type not specified) Light Thai Massage: 33 (3%); Standard Supportive Care: 33 (9%). 33 (3%); 33 (9%). Light Thai Massage: 3 x 45 mins, ND, 2w, + ND; Standard Supportive Care: ND x ND, ND, 1w + ND. 3 x 45 mins, ND, 2w, + ND; ND x ND, ND, 1w + ND. No Numerical Rating Scale (pain): p = 0.001 (between groups) at post; Numerical Rating Scale (fatigue): p = 0.001 (between groups) at post; Numerical Rating Scale (stress or anxiety): p = 0.03 (between groups) at post; Numerical Rating Scale (depression): p = Not Significant (between groups) at post; Numerical Rating Scale (presenting symptom): p = 0.001 (between groups) at post; White Blood Count: p = Not Significant (within groups) (both groups) over time; Lymphocytes: p = 0.04 (between groups) at post; CD4 cells: p = Not Significant (between groups) at post; CD8 cells: p = Not Significant (between groups) at post. Massage effective for: Pain, Sleep, Mood, Physiological, Quality of Life. Authors do not report or mention anything about AEs http://www.ncbi.nlm.nih.gov/pubmed/?term=Effectiveness+of+aromatherapy+with+light+thai+massage+for+cellular+immunity+improvement+in+colorectal+cancer+patients+receiving+chemotherapy
F1 6
Refid 1751
Quick Author Khiewkhern, 2013
Author S. Khiewkhern, S. Promthet, A. Sukprasert, W. Eunhpinitpong and P. Bradshaw
Title Effectiveness of aromatherapy with light thai massage for cellular immunity improvement in colorectal cancer patients receiving chemotherapy
Publication Date 2013
Periodical Asian Pac J Cancer Prev
F8 vol
Volume 14
F10 vol 14
Issue 6
F12 pages
Page Start-End 3903-7
Group Cancer
F15 pages 3903-7
Publication Data Asian Pac J Cancer Prev, vol 14: 6, pages 3903-7
Condition Cancer: Colon cancer
Condition (to hide) 66c (41 M/ 25 F) colorectal cancer patients (mean age = 59 ± 1.6)
Outcome Measures
cleaned up results Numerical Rating Scale (pain) Numerical Rating Scale (fatigue) Numerical Rating Scale (stress or anxiety) Numerical Rating Scale (depression) Numerical Rating Scale (presenting symptom) White Blood Count Lymphocytes CD4 cells CD8 cells
Outcome Measures_ Pain: Numerical Rating Scale; Sleep: Numerical Rating Scale; Stress: Numerical Rating Scale; Mood: Numerical Rating Scale; Quality of Life: Numerical Rating Scale; Physiological: White Blood Count, Lymphocytes, CD4 cells, CD8 cells.
Total Participants 66
Quality Assignment (SIGN 50) 2-Acceptable
Abstract BACKGROUND: Patients with colorectal cancer are usually treated with chemotherapy which reduces the number of blood cells especially white blood cells and consequently increases the risk of infections. Some research studies have reported that aromatherapy massage affects the immune system and improves immune function by for example increasing the numbers of natural killer cells and peripheral blood lymphocytes. However there has been no report of any study which provided good evidence as to whether aromatherapy with Thai massage could improve the immune system in patients with colorectal cancer. The objectives of this study were to determine whether the use of aromatherapy with light Thai massage in patients with colorectal cancer who have received chemotherapy can result in improvement of the cellular immunity and reduce the severity of the common symptoms of side effects. MATERIALS AND METHODS: Sixty-six patients with colorectal cancer in Phichit Hospital Thailand were enrolled in a single-blind randomised-controlled trial. The intervention consisted of three massage sessions with ginger and coconut oil over a 1-week period. The control group received standard supportive care only. Assessments were conducted at pre-assessment and at the end of one week of massage or standard care. Changes from pre-assessment to the end of treatment were measured in terms of white blood cells neutrophils lymphocytes CD4 and CD8 cells and the CD4/CD8 ratio and also the severity of self-rated symptom scores. RESULTS: The main finding was that after adjusting for pre-assessment values the mean lymphocyte count at the post-assessment was significantly higher (P=0.04) in the treatment group than in the controls. The size of this difference suggested that aromatherapy with Thai massage could boost lymphocyte numbers by 11%. The secondary outcomes were that at the post assessment the symptom severity scores for fatigue presenting symptom pain and stress were significantly lower in the massage group than in the standard care controls. CONCLUSIONS: Aromatherapy with light Thai massage can be beneficial for the immune systems of cancer patients who are undergoing chemotherapy by increasing the number of lymphocytes and can help to reduce the severity of common symptoms.
Keywords Adult
Power Not Described
Power1 ND
Provider Type Therapist (type not specified)
Intervention Description: Number Assigned (Dropout Rate) Light Thai Massage: 33 (3%); Standard Supportive Care: 33 (9%).
# Assigned (Dropout Rate)_ 33 (3%); 33 (9%).
double check # assign
Intervention Description: Dosages Light Thai Massage: 3 x 45 mins, ND, 2w, + ND; Standard Supportive Care: ND x ND, ND, 1w + ND.
Intervention Description: Dosages1 3 x 45 mins, ND, 2w, + ND; ND x ND, ND, 1w + ND.
*Meta-Analysis No
Relevant Results _ Numerical Rating Scale (pain): p = 0.001 (between groups) at post; Numerical Rating Scale (fatigue): p = 0.001 (between groups) at post; Numerical Rating Scale (stress or anxiety): p = 0.03 (between groups) at post; Numerical Rating Scale (depression): p = Not Significant (between groups) at post; Numerical Rating Scale (presenting symptom): p = 0.001 (between groups) at post; White Blood Count: p = Not Significant (within groups) (both groups) over time; Lymphocytes: p = 0.04 (between groups) at post; CD4 cells: p = Not Significant (between groups) at post; CD8 cells: p = Not Significant (between groups) at post.
Conclusions Massage effective for: Pain, Sleep, Mood, Physiological, Quality of Life.
Adverse Events Authors do not report or mention anything about AEs
PubMed Link http://www.ncbi.nlm.nih.gov/pubmed/?term=Effectiveness+of+aromatherapy+with+light+thai+massage+for+cellular+immunity+improvement+in+colorectal+cancer+patients+receiving+chemotherapy
7 1896 Kutner, 2008 J. S. Kutner, M. C. Smith, L. Corbin, L. Hemphill, K. Benton, B. K. Mellis, B. Beaty, S. Felton, T. E. Yamashita, L. L. Bryant and D. L. Fairclough Massage therapy versus simple touch to improve pain and mood in patients with advanced cancer: a randomized trial 2008 Ann Intern Med vol 149 vol 149 6 pages 369-79 Cancer pages 369-79 Ann Intern Med, vol 149: 6, pages 369-79 Cancer: Advanced cancer 380c (148 M/232 F) advanced cancer patients (mean age = 65 ± 14.4) Neuropathy Pain Scale (neuropathic pain) Memorial Pain Assessment Card (pain intensity) Brief Pain Inventory (pain interference): Brief Pain Inventory (mean pain) Brief Pain Inventory (worst pain) Memorial Pain Assessment Card (mood) Memorial Symptom Assessment Scale (global distress index) McGill Quality of Life Questionnaire (overall quality of life) McGill Quality of Life Questionnaire (physical well-being) Memorial Symptom Assessment Scale (physical symptoms) Memorial Symptom Assessment Scale (psychological symptoms) Heart Rate Respiration Rate Pain: Neuropathy Pain Scale, Memorial Pain Assessment Card, Brief Pain Inventory; Mood: Memorial Pain Assessment Card, Memorial Symptom Assessment Scale; Stress: Memorial Symptom Assessment Scale; Quality of Life: McGill Quality of Life Questionnaire; 380 3-Low BACKGROUND: Small studies of variable quality suggest that massage therapy may relieve pain and other symptoms. OBJECTIVE: To evaluate the efficacy of massage for decreasing pain and symptom distress and improving quality of life among persons with advanced cancer. DESIGN: Multisite randomized clinical trial. SETTING: Population-based Palliative Care Research Network. PATIENTS: 380 adults with advanced cancer who were experiencing moderate-to-severe pain; 90% were enrolled in hospice. INTERVENTION: Six 30-minute massage or simple-touch sessions over 2 weeks. MEASUREMENTS: Primary outcomes were immediate (Memorial Pain Assessment Card 0- to 10-point scale) and sustained (Brief Pain Inventory [BPI] 0- to 10-point scale) change in pain. Secondary outcomes were immediate change in mood (Memorial Pain Assessment Card) and 60-second heart and respiratory rates and sustained change in quality of life (McGill Quality of Life Questionnaire 0- to 10-point scale) symptom distress (Memorial Symptom Assessment Scale 0- to 4-point scale) and analgesic medication use (parenteral morphine equivalents [mg/d]). Immediate outcomes were obtained just before and after each treatment session. Sustained outcomes were obtained at baseline and weekly for 3 weeks. RESULTS: 298 persons were included in the immediate outcome analysis and 348 in the sustained outcome analysis. A total of 82 persons did not receive any allocated study treatments (37 massage patients 45 control participants). Both groups demonstrated immediate improvement in pain (massage -1.87 points [95% CI -2.07 to -1.67 points]; control -0.97 point [CI -1.18 to -0.76 points]) and mood (massage 1.58 points [CI 1.40 to 1.76 points]; control 0.97 point [CI 0.78 to 1.16 points]). Massage was superior for both immediate pain and mood (mean difference 0.90 and 0.61 points respectively; P < 0.001). No between-group mean differences occurred over time in sustained pain (BPI mean pain 0.07 point [CI -0.23 to 0.37 points]; BPI worst pain -0.14 point [CI -0.59 to 0.31 points]) quality of life (McGill Quality of Life Questionnaire overall 0.08 point [CI -0.37 to 0.53 points]) symptom distress (Memorial Symptom Assessment Scale global distress index -0.002 point [CI -0.12 to 0.12 points]) or analgesic medication use (parenteral morphine equivalents -0.10 mg/d [CI -0.25 to 0.05 mg/d]). LIMITATIONS: The immediate outcome measures were obtained by unblinded study therapists possibly leading to reporting bias and the overestimation of a beneficial effect. The generalizability to all patients with advanced cancer is uncertain. The differential beneficial effect of massage therapy over simple touch is not conclusive without a usual care control group. CONCLUSION: Massage may have immediately beneficial effects on pain and mood among patients with advanced cancer. Given the lack of sustained effects and the observed improvements in both study groups the potential benefits of attention and simple touch should also be considered in this patient population. Affect, drug effects Not Described ND Massage therapist Massage Therapy: 188 (40%); Simple Touch: 192 (52%). 188 (40%); 192 (52%). Massage Therapy: 6 x 30 mins, ND, 2w + ND; Simple Touch: 6 x 30 mins, ND, 2w + ND. 6 x 30 mins, ND, 2w + ND; 6 x 30 mins, ND, 2w + ND. No Neuropathy Pain Scale (neuropathic pain): p = Not Described; Memorial Pain Assessment Card (pain intensity): p < 0.0001 (between groups) immediate effect over time; Brief Pain Inventory (pain interference): p = Not Significant (between groups) sustained effect over time; Brief Pain Inventory (mean pain): p = Not Significant (between groups) sustained effect over time; Brief Pain Inventory (worst pain): p = Not Significant (between groups) sustained effect over time; Memorial Pain Assessment Card (mood): p < 0.0001 (between groups) immediate effect over time; Memorial Symptom Assessment Scale (global distress index): p = Not Significant (between groups) sustained effect over time; McGill Quality of Life Questionnaire (overall quality of life): p = Not Significant (between groups) sustained effect over time; McGill Quality of Life Questionnaire (physical well-being): p = Not Significant (between groups) sustained effect over time; Memorial Symptom Assessment Scale (physical symptoms): p = Not Significant (between groups) sustained effect over time; Memorial Symptom Assessment Scale (psychological symptoms): p = Not Significant (between groups) sustained effect over time; Heart Rate: p = Not Significant (between groups) immediate effect over time; Respiration Rate: p = Not Significant (between groups) immediate effect over time. Massage effective for: Pain, Mood. Mortality rates during the study were similar between study arms (26 (13.8%) for massage vs. 33 (17.2%) for control, P=0.40). Two (1.1%) serious adverse events occurred in the massage group and 6 (3.1%) in control (P=0.28). Massage group adverse events in http://www.ncbi.nlm.nih.gov/pubmed/?term=Massage+therapy+versus+simple+touch+to+improve+pain+and+mood+in+patients+with+advanced+cancer%3A+a+randomized+trial
F1 7
Refid 1896
Quick Author Kutner, 2008
Author J. S. Kutner, M. C. Smith, L. Corbin, L. Hemphill, K. Benton, B. K. Mellis, B. Beaty, S. Felton, T. E. Yamashita, L. L. Bryant and D. L. Fairclough
Title Massage therapy versus simple touch to improve pain and mood in patients with advanced cancer: a randomized trial
Publication Date 2008
Periodical Ann Intern Med
F8 vol
Volume 149
F10 vol 149
Issue 6
F12 pages
Page Start-End 369-79
Group Cancer
F15 pages 369-79
Publication Data Ann Intern Med, vol 149: 6, pages 369-79
Condition Cancer: Advanced cancer
Condition (to hide) 380c (148 M/232 F) advanced cancer patients (mean age = 65 ± 14.4)
Outcome Measures
cleaned up results Neuropathy Pain Scale (neuropathic pain) Memorial Pain Assessment Card (pain intensity) Brief Pain Inventory (pain interference): Brief Pain Inventory (mean pain) Brief Pain Inventory (worst pain) Memorial Pain Assessment Card (mood) Memorial Symptom Assessment Scale (global distress index) McGill Quality of Life Questionnaire (overall quality of life) McGill Quality of Life Questionnaire (physical well-being) Memorial Symptom Assessment Scale (physical symptoms) Memorial Symptom Assessment Scale (psychological symptoms) Heart Rate Respiration Rate
Outcome Measures_ Pain: Neuropathy Pain Scale, Memorial Pain Assessment Card, Brief Pain Inventory; Mood: Memorial Pain Assessment Card, Memorial Symptom Assessment Scale; Stress: Memorial Symptom Assessment Scale; Quality of Life: McGill Quality of Life Questionnaire;
Total Participants 380
Quality Assignment (SIGN 50) 3-Low
Abstract BACKGROUND: Small studies of variable quality suggest that massage therapy may relieve pain and other symptoms. OBJECTIVE: To evaluate the efficacy of massage for decreasing pain and symptom distress and improving quality of life among persons with advanced cancer. DESIGN: Multisite randomized clinical trial. SETTING: Population-based Palliative Care Research Network. PATIENTS: 380 adults with advanced cancer who were experiencing moderate-to-severe pain; 90% were enrolled in hospice. INTERVENTION: Six 30-minute massage or simple-touch sessions over 2 weeks. MEASUREMENTS: Primary outcomes were immediate (Memorial Pain Assessment Card 0- to 10-point scale) and sustained (Brief Pain Inventory [BPI] 0- to 10-point scale) change in pain. Secondary outcomes were immediate change in mood (Memorial Pain Assessment Card) and 60-second heart and respiratory rates and sustained change in quality of life (McGill Quality of Life Questionnaire 0- to 10-point scale) symptom distress (Memorial Symptom Assessment Scale 0- to 4-point scale) and analgesic medication use (parenteral morphine equivalents [mg/d]). Immediate outcomes were obtained just before and after each treatment session. Sustained outcomes were obtained at baseline and weekly for 3 weeks. RESULTS: 298 persons were included in the immediate outcome analysis and 348 in the sustained outcome analysis. A total of 82 persons did not receive any allocated study treatments (37 massage patients 45 control participants). Both groups demonstrated immediate improvement in pain (massage -1.87 points [95% CI -2.07 to -1.67 points]; control -0.97 point [CI -1.18 to -0.76 points]) and mood (massage 1.58 points [CI 1.40 to 1.76 points]; control 0.97 point [CI 0.78 to 1.16 points]). Massage was superior for both immediate pain and mood (mean difference 0.90 and 0.61 points respectively; P < 0.001). No between-group mean differences occurred over time in sustained pain (BPI mean pain 0.07 point [CI -0.23 to 0.37 points]; BPI worst pain -0.14 point [CI -0.59 to 0.31 points]) quality of life (McGill Quality of Life Questionnaire overall 0.08 point [CI -0.37 to 0.53 points]) symptom distress (Memorial Symptom Assessment Scale global distress index -0.002 point [CI -0.12 to 0.12 points]) or analgesic medication use (parenteral morphine equivalents -0.10 mg/d [CI -0.25 to 0.05 mg/d]). LIMITATIONS: The immediate outcome measures were obtained by unblinded study therapists possibly leading to reporting bias and the overestimation of a beneficial effect. The generalizability to all patients with advanced cancer is uncertain. The differential beneficial effect of massage therapy over simple touch is not conclusive without a usual care control group. CONCLUSION: Massage may have immediately beneficial effects on pain and mood among patients with advanced cancer. Given the lack of sustained effects and the observed improvements in both study groups the potential benefits of attention and simple touch should also be considered in this patient population.
Keywords Affect, drug effects
Power Not Described
Power1 ND
Provider Type Massage therapist
Intervention Description: Number Assigned (Dropout Rate) Massage Therapy: 188 (40%); Simple Touch: 192 (52%).
# Assigned (Dropout Rate)_ 188 (40%); 192 (52%).
double check # assign
Intervention Description: Dosages Massage Therapy: 6 x 30 mins, ND, 2w + ND; Simple Touch: 6 x 30 mins, ND, 2w + ND.
Intervention Description: Dosages1 6 x 30 mins, ND, 2w + ND; 6 x 30 mins, ND, 2w + ND.
*Meta-Analysis No
Relevant Results _ Neuropathy Pain Scale (neuropathic pain): p = Not Described; Memorial Pain Assessment Card (pain intensity): p < 0.0001 (between groups) immediate effect over time; Brief Pain Inventory (pain interference): p = Not Significant (between groups) sustained effect over time; Brief Pain Inventory (mean pain): p = Not Significant (between groups) sustained effect over time; Brief Pain Inventory (worst pain): p = Not Significant (between groups) sustained effect over time; Memorial Pain Assessment Card (mood): p < 0.0001 (between groups) immediate effect over time; Memorial Symptom Assessment Scale (global distress index): p = Not Significant (between groups) sustained effect over time; McGill Quality of Life Questionnaire (overall quality of life): p = Not Significant (between groups) sustained effect over time; McGill Quality of Life Questionnaire (physical well-being): p = Not Significant (between groups) sustained effect over time; Memorial Symptom Assessment Scale (physical symptoms): p = Not Significant (between groups) sustained effect over time; Memorial Symptom Assessment Scale (psychological symptoms): p = Not Significant (between groups) sustained effect over time; Heart Rate: p = Not Significant (between groups) immediate effect over time; Respiration Rate: p = Not Significant (between groups) immediate effect over time.
Conclusions Massage effective for: Pain, Mood.
Adverse Events Mortality rates during the study were similar between study arms (26 (13.8%) for massage vs. 33 (17.2%) for control, P=0.40). Two (1.1%) serious adverse events occurred in the massage group and 6 (3.1%) in control (P=0.28). Massage group adverse events in
PubMed Link http://www.ncbi.nlm.nih.gov/pubmed/?term=Massage+therapy+versus+simple+touch+to+improve+pain+and+mood+in+patients+with+advanced+cancer%3A+a+randomized+trial
8 2054 Listing, 2009* M. Listing, A. Reisshauer, M. Krohn, B. Voigt, G. Tjahono, J. Becker, B. F. Klapp and M. Rauchfuss Massage therapy reduces physical discomfort and improves mood disturbances in women with breast cancer 2009 Psychooncology vol 18 vol 18 12 pages 1290-9 Cancer pages 1290-9 Psychooncology, vol 18: 12, pages 1290-9 Cancer: Breast cancer 86c female breast cancer patients (mean age = 59) Short Form-8 Health Survey Health Survey (bodily pain) Giessen Complaints Inventory (pain of limbs) European Organization of Research and Treatment of Cancer Quality of Life breast module (breast symptoms) European Organization of Research and Treatment of Cancer Quality of Life breast module (arm symptoms) Giessen Complaints Inventory (fatigue) Berlin Mood Questionnaire (tiredness) Berlin Mood Questionnaire (anger) Berlin Mood Questionnaire (anxious depression) Berlin Mood Questionnaire (listlessness) Berlin Mood Questionnaire (involvement) Berlin Mood Questionnaire (elevated mood) Pain: Short Form-8 Health Survey Health Survey, Giessen Complaints Inventory; Quality of Life: European Organization of Research and Treatment of Cancer Quality of Life breast module; Sleep: Giessen Complaints Inventory; Mood: Berlin Mood Questionnaire. 86 2-Acceptable BACKGROUND. A randomized controlled trial was conducted to investigate the efficacy of classical massage treatment in reducing breast cancer-related symptoms and in improving mood disturbances. METHODS. Women diagnosed with primary breast cancer were randomized into an intervention group and a control group. For a period of 5 weeks the intervention group received bi-weekly 30-min classical massages in the back and head-neck areas. The control group received no additional treatment to their routine healthcare. To evaluate treatment efficacy the following validated questionnaires were administrated at baseline (T1) at the end of the intervention (T2) and at a followup at 11 weeks (T3): the Short Form-8 Health Survey the European Organization of Research and Treatment of Cancer quality of life questionnaire breast module (EORTC QLQ-BR23) the Giessen Complaints Inventory (GBB) and the Berlin Mood Questionnaire (BSF). RESULTS. Eighty-six eligible women (mean age: 59 years) were enrolled in the study. A significantly higher reduction of physical discomfort was found in the intervention group compared with the control group at T2 (p=0.001) and at T3 (p=0.038). A decrease in fatigue was also observed. Women in the intervention group reported significantly lower mood disturbances at T2 (p<0.01) but not at T3. The effect of treatment on mood disturbances was significantly higher if a patient was treated continuously by the same masseur. CONCLUSION. Classical massage seems to be an effective adjuvant treatment for reducing physical discomfort and fatigue and improving mood disturbances in women with early stage breast cancer. Adult Not Described ND Massage therapist Massage Therapy: 50 (12%); No Treatment: 36 (22%). 50 (12%); 36 (22%). Massage Therapy: 10 x 30 mins, 2x/w, 5w + ND; No Treatment: ND x ND, ND, 11w + ND. 10 x 30 mins, 2x/w, 5w + ND; ND x ND, ND, 11w + ND. Yes *Short Form-8 Health Survey Health Survey (bodily pain): p = 0.0001 (between groups) (Massage Therapy / No Treatment) at 5w; p = 0.001 (between groups) (Massage Therapy / No Treatment) at 11w FU; p = Not Significant (between groups) (1 masseur / multiple masseurs) over time, Effect Size = -0.81, No Treatment, pre / post; Giessen Complaints Inventory (pain of limbs): p = 0.03 (between groups) (Massage Therapy / No Treatment) at 5w; p = Not Significant (between groups) (Massage Therapy / No Treatment) at 11w FU; p = Not Significant (between groups) (1 masseur / multiple masseurs) over time; European Organization of Research and Treatment of Cancer Quality of Life breast module (breast symptoms): p = 0.04 (between groups) (Massage Therapy / No Treatment) at 5w; p = Not Significant (between groups) (Massage Therapy / No Treatment) at 11w FU; p = 0.02 (between groups) (1 masseur / multiple masseurs) over time; European Organization of Research and Treatment of Cancer Quality of Life breast module (arm symptoms): p = Not Significant (between groups) (Massage Therapy / No Treatment) at 5w and 11w FU; p = Not Significant (between groups) (1 masseur / multiple masseurs) over time; Giessen Complaints Inventory (fatigue): p = Not Significant (between groups) (1 masseur / multiple masseurs) over time; Berlin Mood Questionnaire (tiredness): p = 0.03 (between groups) (1 masseur / multiple masseurs) over time; Berlin Mood Questionnaire (anger): p = 0.02 (between groups) (1 masseur / multiple masseurs) over time; Berlin Mood Questionnaire (anxious depression): p = 0.0007 (between groups) (1 masseur / multiple masseurs) over time; Berlin Mood Questionnaire (listlessness): p = Not Significant (between groups) (1 masseur / multiple masseurs) over time; Berlin Mood Questionnaire (involvement): p = Not Significant (between groups) (1 masseur / multiple masseurs) over time; Berlin Mood Questionnaire (elevated mood): p = 0.016 (between groups) (1 masseur / multiple masseurs) over time. Massage effective for: Pain, Quality of Life, Sleep, Mood. Authors do not report or mention anything about AEs http://www.ncbi.nlm.nih.gov/pubmed/?term=Massage+therapy+reduces+physical+discomfort+and+improves+mood+disturbances+in+women+with+breast+cancer
F1 8
Refid 2054
Quick Author Listing, 2009*
Author M. Listing, A. Reisshauer, M. Krohn, B. Voigt, G. Tjahono, J. Becker, B. F. Klapp and M. Rauchfuss
Title Massage therapy reduces physical discomfort and improves mood disturbances in women with breast cancer
Publication Date 2009
Periodical Psychooncology
F8 vol
Volume 18
F10 vol 18
Issue 12
F12 pages
Page Start-End 1290-9
Group Cancer
F15 pages 1290-9
Publication Data Psychooncology, vol 18: 12, pages 1290-9
Condition Cancer: Breast cancer
Condition (to hide) 86c female breast cancer patients (mean age = 59)
Outcome Measures
cleaned up results Short Form-8 Health Survey Health Survey (bodily pain) Giessen Complaints Inventory (pain of limbs) European Organization of Research and Treatment of Cancer Quality of Life breast module (breast symptoms) European Organization of Research and Treatment of Cancer Quality of Life breast module (arm symptoms) Giessen Complaints Inventory (fatigue) Berlin Mood Questionnaire (tiredness) Berlin Mood Questionnaire (anger) Berlin Mood Questionnaire (anxious depression) Berlin Mood Questionnaire (listlessness) Berlin Mood Questionnaire (involvement) Berlin Mood Questionnaire (elevated mood)
Outcome Measures_ Pain: Short Form-8 Health Survey Health Survey, Giessen Complaints Inventory; Quality of Life: European Organization of Research and Treatment of Cancer Quality of Life breast module; Sleep: Giessen Complaints Inventory; Mood: Berlin Mood Questionnaire.
Total Participants 86
Quality Assignment (SIGN 50) 2-Acceptable
Abstract BACKGROUND. A randomized controlled trial was conducted to investigate the efficacy of classical massage treatment in reducing breast cancer-related symptoms and in improving mood disturbances. METHODS. Women diagnosed with primary breast cancer were randomized into an intervention group and a control group. For a period of 5 weeks the intervention group received bi-weekly 30-min classical massages in the back and head-neck areas. The control group received no additional treatment to their routine healthcare. To evaluate treatment efficacy the following validated questionnaires were administrated at baseline (T1) at the end of the intervention (T2) and at a followup at 11 weeks (T3): the Short Form-8 Health Survey the European Organization of Research and Treatment of Cancer quality of life questionnaire breast module (EORTC QLQ-BR23) the Giessen Complaints Inventory (GBB) and the Berlin Mood Questionnaire (BSF). RESULTS. Eighty-six eligible women (mean age: 59 years) were enrolled in the study. A significantly higher reduction of physical discomfort was found in the intervention group compared with the control group at T2 (p=0.001) and at T3 (p=0.038). A decrease in fatigue was also observed. Women in the intervention group reported significantly lower mood disturbances at T2 (p<0.01) but not at T3. The effect of treatment on mood disturbances was significantly higher if a patient was treated continuously by the same masseur. CONCLUSION. Classical massage seems to be an effective adjuvant treatment for reducing physical discomfort and fatigue and improving mood disturbances in women with early stage breast cancer.
Keywords Adult
Power Not Described
Power1 ND
Provider Type Massage therapist
Intervention Description: Number Assigned (Dropout Rate) Massage Therapy: 50 (12%); No Treatment: 36 (22%).
# Assigned (Dropout Rate)_ 50 (12%); 36 (22%).
double check # assign
Intervention Description: Dosages Massage Therapy: 10 x 30 mins, 2x/w, 5w + ND; No Treatment: ND x ND, ND, 11w + ND.
Intervention Description: Dosages1 10 x 30 mins, 2x/w, 5w + ND; ND x ND, ND, 11w + ND.
*Meta-Analysis Yes
Relevant Results _ *Short Form-8 Health Survey Health Survey (bodily pain): p = 0.0001 (between groups) (Massage Therapy / No Treatment) at 5w; p = 0.001 (between groups) (Massage Therapy / No Treatment) at 11w FU; p = Not Significant (between groups) (1 masseur / multiple masseurs) over time, Effect Size = -0.81, No Treatment, pre / post; Giessen Complaints Inventory (pain of limbs): p = 0.03 (between groups) (Massage Therapy / No Treatment) at 5w; p = Not Significant (between groups) (Massage Therapy / No Treatment) at 11w FU; p = Not Significant (between groups) (1 masseur / multiple masseurs) over time; European Organization of Research and Treatment of Cancer Quality of Life breast module (breast symptoms): p = 0.04 (between groups) (Massage Therapy / No Treatment) at 5w; p = Not Significant (between groups) (Massage Therapy / No Treatment) at 11w FU; p = 0.02 (between groups) (1 masseur / multiple masseurs) over time; European Organization of Research and Treatment of Cancer Quality of Life breast module (arm symptoms): p = Not Significant (between groups) (Massage Therapy / No Treatment) at 5w and 11w FU; p = Not Significant (between groups) (1 masseur / multiple masseurs) over time; Giessen Complaints Inventory (fatigue): p = Not Significant (between groups) (1 masseur / multiple masseurs) over time; Berlin Mood Questionnaire (tiredness): p = 0.03 (between groups) (1 masseur / multiple masseurs) over time; Berlin Mood Questionnaire (anger): p = 0.02 (between groups) (1 masseur / multiple masseurs) over time; Berlin Mood Questionnaire (anxious depression): p = 0.0007 (between groups) (1 masseur / multiple masseurs) over time; Berlin Mood Questionnaire (listlessness): p = Not Significant (between groups) (1 masseur / multiple masseurs) over time; Berlin Mood Questionnaire (involvement): p = Not Significant (between groups) (1 masseur / multiple masseurs) over time; Berlin Mood Questionnaire (elevated mood): p = 0.016 (between groups) (1 masseur / multiple masseurs) over time.
Conclusions Massage effective for: Pain, Quality of Life, Sleep, Mood.
Adverse Events Authors do not report or mention anything about AEs
PubMed Link http://www.ncbi.nlm.nih.gov/pubmed/?term=Massage+therapy+reduces+physical+discomfort+and+improves+mood+disturbances+in+women+with+breast+cancer
9 2676 Post-White, 2009 J. Post-White, M. Fitzgerald, K. Savik, M. C. Hooke, A. B. Hannahan and S. F. Sencer Massage therapy for children with cancer 2009 J Pediatr Oncol Nurs vol 26 vol 26 1 pages 16-28 Cancer pages 16-28 J Pediatr Oncol Nurs, vol 26: 1, pages 16-28 Cancer: Pediatric cancer 25 (15M/10F) pediatric cancer patients (mean age = ND) Visual Analog Scale (pain) Heart Rate (auscultation) Lansky Play Performance Scale (fatigue) State-Trait Anxiety Inventory for Children (state anxiety) Salivary cortisol Pain: Visual Analog Scale; Sleep: Lansky Play Performance Scale; Mood: State-Trait Anxiety Inventory for Children; Physiological: Heart Rate, Salivary cortisol. 25 3-Low This pilot study aimed to determine the feasibility of providing massage to children with cancer to reduce symptoms in children and anxiety in parents. Twenty-three children/parent dyads were enrolled; 17 completed all data points. Children with cancer ages 1 to 18 years received at least 2 identical cycles of chemotherapy and one parent participated in the 2-period crossover design in which 4 weekly massage sessions alternated with 4 weekly quiet-time control sessions. Changes in relaxation (heart and respiratory rates blood pressure and salivary cortisol level) and symptoms (pain nausea anxiety and fatigue) were assessed in children; anxiety and fatigue were measured in parents. Massage was more effective than quiet time at reducing heart rate in children anxiety in children less than age 14 years and parent anxiety. There were no significant changes in blood pressure cortisol pain nausea or fatigue. Children reported that massage helped them feel better lessened their anxiety and worries and had longer lasting effects than quiet time. Massage in children with cancer is feasible and appears to decrease anxiety in parents and younger children. Adolescent Not Described ND Massage therapist Massage: 12 (17%); Quiet Time: 13 (0%). 12 (17%); 13 (0%). Massage: 4 x ND, weekly, 4w + ND; Quiet Time: 4 x ND, weekly, 4w + ND. 4 x ND, weekly, 4w + ND; 4 x ND, weekly, 4w + ND. No Visual Analog Scale (pain): p = Not Significant (between groups) over time; Heart Rate (auscultation): p = 0.02 (between groups) over time; Lansky Play Performance Scale (fatigue): p = Not Significant (between groups) over time; State-Trait Anxiety Inventory for Children (state anxiety): p = 0.04 (between groups) over time; Salivary cortisol: p = Not Significant (between groups) over time. Massage effective for: Physiological, Mood. Authors do not report or mention anything about AEs http://www.ncbi.nlm.nih.gov/pubmed/19074355
F1 9
Refid 2676
Quick Author Post-White, 2009
Author J. Post-White, M. Fitzgerald, K. Savik, M. C. Hooke, A. B. Hannahan and S. F. Sencer
Title Massage therapy for children with cancer
Publication Date 2009
Periodical J Pediatr Oncol Nurs
F8 vol
Volume 26
F10 vol 26
Issue 1
F12 pages
Page Start-End 16-28
Group Cancer
F15 pages 16-28
Publication Data J Pediatr Oncol Nurs, vol 26: 1, pages 16-28
Condition Cancer: Pediatric cancer
Condition (to hide) 25 (15M/10F) pediatric cancer patients (mean age = ND)
Outcome Measures
cleaned up results Visual Analog Scale (pain) Heart Rate (auscultation) Lansky Play Performance Scale (fatigue) State-Trait Anxiety Inventory for Children (state anxiety) Salivary cortisol
Outcome Measures_ Pain: Visual Analog Scale; Sleep: Lansky Play Performance Scale; Mood: State-Trait Anxiety Inventory for Children; Physiological: Heart Rate, Salivary cortisol.
Total Participants 25
Quality Assignment (SIGN 50) 3-Low
Abstract This pilot study aimed to determine the feasibility of providing massage to children with cancer to reduce symptoms in children and anxiety in parents. Twenty-three children/parent dyads were enrolled; 17 completed all data points. Children with cancer ages 1 to 18 years received at least 2 identical cycles of chemotherapy and one parent participated in the 2-period crossover design in which 4 weekly massage sessions alternated with 4 weekly quiet-time control sessions. Changes in relaxation (heart and respiratory rates blood pressure and salivary cortisol level) and symptoms (pain nausea anxiety and fatigue) were assessed in children; anxiety and fatigue were measured in parents. Massage was more effective than quiet time at reducing heart rate in children anxiety in children less than age 14 years and parent anxiety. There were no significant changes in blood pressure cortisol pain nausea or fatigue. Children reported that massage helped them feel better lessened their anxiety and worries and had longer lasting effects than quiet time. Massage in children with cancer is feasible and appears to decrease anxiety in parents and younger children.
Keywords Adolescent
Power Not Described
Power1 ND
Provider Type Massage therapist
Intervention Description: Number Assigned (Dropout Rate) Massage: 12 (17%); Quiet Time: 13 (0%).
# Assigned (Dropout Rate)_ 12 (17%); 13 (0%).
double check # assign
Intervention Description: Dosages Massage: 4 x ND, weekly, 4w + ND; Quiet Time: 4 x ND, weekly, 4w + ND.
Intervention Description: Dosages1 4 x ND, weekly, 4w + ND; 4 x ND, weekly, 4w + ND.
*Meta-Analysis No
Relevant Results _ Visual Analog Scale (pain): p = Not Significant (between groups) over time; Heart Rate (auscultation): p = 0.02 (between groups) over time; Lansky Play Performance Scale (fatigue): p = Not Significant (between groups) over time; State-Trait Anxiety Inventory for Children (state anxiety): p = 0.04 (between groups) over time; Salivary cortisol: p = Not Significant (between groups) over time.
Conclusions Massage effective for: Physiological, Mood.
Adverse Events Authors do not report or mention anything about AEs
PubMed Link http://www.ncbi.nlm.nih.gov/pubmed/19074355
10 2677 Post-White, 2003* J. Post-White, M. E. Kinney, K. Savik, J. B. Gau, C. Wilcox and I. Lerner Therapeutic massage and healing touch improve symptoms in cancer 2003 Integr Cancer Ther vol 2 vol 2 4 pages 332-44 Cancer pages 332-44 Integr Cancer Ther, vol 2: 4, pages 332-44 Cancer 230ac (32 M/198 F) cancer patients (mean age = 54.7) Brief Pain Inventory (pain) Profile of Mood States subscales (anxiety) Profile of Mood States subscales (fatigue) Profile of Mood States subscales (mood disturbance) Systolic Blood Pressure Diastolic Blood Pressure Heart Rate Respiration Rate Pain: Brief Pain Inventory; Mood: Profile of Mood States subscales; Physiological: Systolic Blood Pressure, Diastolic Blood Pressure, Heart Rate, Respiration Rate. 230 2-Acceptable Complementary therapies are increasingly used to reduce side effects of cancer treatment without evidence for their effectiveness. In a randomized prospective 2-period crossover intervention study the authors tested the effects of therapeutic massage (MT) and healing touch (HT) in comparison to presence alone or standard care in inducing relaxation and reducing symptoms in 230 subjects. MT and HT lowered blood pressure respiratory rate (RR) and heart rate (HR). MT lowered anxiety and HT lowered fatigue and both lowered total mood disturbance. Pain ratings were lower after MT and HT with 4-week nonsteroidal anti-inflammatory drug use less during MT. There were no effects on nausea. Presence reduced RR and HR but did not differ from standard care on any measure of pain nausea mood states anxiety or fatigue. MT and HT are more effective than presence alone or standard care in reducing pain mood disturbance and fatigue in patients receiving cancer chemotherapy. Adult Yes, power achieved Yes Massage therapist Massage Therapy: ND (ND); Healing Touch: ND (ND); Caring Presence (Active Control): ND (ND); Usual Care: ND (ND). ND (ND); ND (ND); ND (ND); ND (ND). Massage Therapy: 4 x 45 mins, weekly, 4w + ND; Healing Touch: 4 x ND, weekly, 4w + ND; Caring Presence (Active Control): 4 x 45 mins, weekly, 4w + ND; Usual Care: 4 x ND, weekly, 4w + ND. 4 x 45 mins, weekly, 4w + ND; 4 x ND, weekly, 4w + ND; 4 x 45 mins, weekly, 4w + ND; 4 x ND, weekly, 4w + ND. Yes *Brief Pain Inventory (pain): p < 0.001 (between groups) (Massage Therapy / presence), p < 0.001 (between groups) (Active Control / presence), p < 0.001 (between groups) (Massage Therapy / Standard care), p < 0.011 (between groups) (Active Control / Standard care) over time, Effect Size = -0.31, Active Control, pre / post; *Profile of Mood States subscales (anxiety): p = 0.02 (between groups) (Massage Therapy / Standard care), Effect Size = -0.27, Active Control, pre / post; *Profile of Mood States subscales (fatigue): p = Not Significant (between groups) (Massage Therapy / Standard care), p = 0.03 (between groups) (Active Control / standard care) over time, Effect Size = -0.23, Active Control, pre / post; Profile of Mood States subscales (mood disturbance): p = 0.02 (between groups) (Massage Therapy / Standard care), p = 0.02 (between groups) (Active Control / standard care), p = 0.02 (between groups) (presence / Standard care) over time; Systolic Blood Pressure: p < 0.001 (between groups) (Massage Therapy / presence), p < 0.001 (between groups) (Active Control / presence), p < 0.001 (between groups) (Massage Therapy / standard care), p < 0.001 (between groups) (Active Control / standard care) over time; Diastolic Blood Pressure: p < 0.001 (between groups) (Massage Therapy / standard care), p < 0.001 (between groups) (Active Control / standard care) over time; Heart Rate: p = 0.011 (between groups) (Massage Therapy / presence), p = 0.011 (between groups) (Active Control / presence), p < 0.001 (between groups) (Massage Therapy / Standard care), p < 0.001 (between groups) (Active Control / Standard care) over time; Respiration Rate: p < 0.001 (between groups) (Massage Therapy / presence), p < 0.001 (between groups) (Active Control / presence), p < 0.001 (between groups) (Massage Therapy / Standard care), p < 0.001 (between groups) (Active Control / Standard care) over time. Massage effective for: Pain, Physiological. Authors report NO AEs occurred http://www.ncbi.nlm.nih.gov/pubmed/?term=kinney++Therapeutic+massage+and+healing+touch+improve+symptoms+in+cancer
F1 10
Refid 2677
Quick Author Post-White, 2003*
Author J. Post-White, M. E. Kinney, K. Savik, J. B. Gau, C. Wilcox and I. Lerner
Title Therapeutic massage and healing touch improve symptoms in cancer
Publication Date 2003
Periodical Integr Cancer Ther
F8 vol
Volume 2
F10 vol 2
Issue 4
F12 pages
Page Start-End 332-44
Group Cancer
F15 pages 332-44
Publication Data Integr Cancer Ther, vol 2: 4, pages 332-44
Condition Cancer
Condition (to hide) 230ac (32 M/198 F) cancer patients (mean age = 54.7)
Outcome Measures
cleaned up results Brief Pain Inventory (pain) Profile of Mood States subscales (anxiety) Profile of Mood States subscales (fatigue) Profile of Mood States subscales (mood disturbance) Systolic Blood Pressure Diastolic Blood Pressure Heart Rate Respiration Rate
Outcome Measures_ Pain: Brief Pain Inventory; Mood: Profile of Mood States subscales; Physiological: Systolic Blood Pressure, Diastolic Blood Pressure, Heart Rate, Respiration Rate.
Total Participants 230
Quality Assignment (SIGN 50) 2-Acceptable
Abstract Complementary therapies are increasingly used to reduce side effects of cancer treatment without evidence for their effectiveness. In a randomized prospective 2-period crossover intervention study the authors tested the effects of therapeutic massage (MT) and healing touch (HT) in comparison to presence alone or standard care in inducing relaxation and reducing symptoms in 230 subjects. MT and HT lowered blood pressure respiratory rate (RR) and heart rate (HR). MT lowered anxiety and HT lowered fatigue and both lowered total mood disturbance. Pain ratings were lower after MT and HT with 4-week nonsteroidal anti-inflammatory drug use less during MT. There were no effects on nausea. Presence reduced RR and HR but did not differ from standard care on any measure of pain nausea mood states anxiety or fatigue. MT and HT are more effective than presence alone or standard care in reducing pain mood disturbance and fatigue in patients receiving cancer chemotherapy.
Keywords Adult
Power Yes, power achieved
Power1 Yes
Provider Type Massage therapist
Intervention Description: Number Assigned (Dropout Rate) Massage Therapy: ND (ND); Healing Touch: ND (ND); Caring Presence (Active Control): ND (ND); Usual Care: ND (ND).
# Assigned (Dropout Rate)_ ND (ND); ND (ND); ND (ND); ND (ND).
double check # assign
Intervention Description: Dosages Massage Therapy: 4 x 45 mins, weekly, 4w + ND; Healing Touch: 4 x ND, weekly, 4w + ND; Caring Presence (Active Control): 4 x 45 mins, weekly, 4w + ND; Usual Care: 4 x ND, weekly, 4w + ND.
Intervention Description: Dosages1 4 x 45 mins, weekly, 4w + ND; 4 x ND, weekly, 4w + ND; 4 x 45 mins, weekly, 4w + ND; 4 x ND, weekly, 4w + ND.
*Meta-Analysis Yes
Relevant Results _ *Brief Pain Inventory (pain): p < 0.001 (between groups) (Massage Therapy / presence), p < 0.001 (between groups) (Active Control / presence), p < 0.001 (between groups) (Massage Therapy / Standard care), p < 0.011 (between groups) (Active Control / Standard care) over time, Effect Size = -0.31, Active Control, pre / post; *Profile of Mood States subscales (anxiety): p = 0.02 (between groups) (Massage Therapy / Standard care), Effect Size = -0.27, Active Control, pre / post; *Profile of Mood States subscales (fatigue): p = Not Significant (between groups) (Massage Therapy / Standard care), p = 0.03 (between groups) (Active Control / standard care) over time, Effect Size = -0.23, Active Control, pre / post; Profile of Mood States subscales (mood disturbance): p = 0.02 (between groups) (Massage Therapy / Standard care), p = 0.02 (between groups) (Active Control / standard care), p = 0.02 (between groups) (presence / Standard care) over time; Systolic Blood Pressure: p < 0.001 (between groups) (Massage Therapy / presence), p < 0.001 (between groups) (Active Control / presence), p < 0.001 (between groups) (Massage Therapy / standard care), p < 0.001 (between groups) (Active Control / standard care) over time; Diastolic Blood Pressure: p < 0.001 (between groups) (Massage Therapy / standard care), p < 0.001 (between groups) (Active Control / standard care) over time; Heart Rate: p = 0.011 (between groups) (Massage Therapy / presence), p = 0.011 (between groups) (Active Control / presence), p < 0.001 (between groups) (Massage Therapy / Standard care), p < 0.001 (between groups) (Active Control / Standard care) over time; Respiration Rate: p < 0.001 (between groups) (Massage Therapy / presence), p < 0.001 (between groups) (Active Control / presence), p < 0.001 (between groups) (Massage Therapy / Standard care), p < 0.001 (between groups) (Active Control / Standard care) over time.
Conclusions Massage effective for: Pain, Physiological.
Adverse Events Authors report NO AEs occurred
PubMed Link http://www.ncbi.nlm.nih.gov/pubmed/?term=kinney++Therapeutic+massage+and+healing+touch+improve+symptoms+in+cancer
11 2818 Rosen, 2013-cancer J. R. Rosen, R. Lawrence, M. Bouchard, G. Doros, P. Gardiner, R. Saper Massage for perioperative pain and anxiety in placement of vascular access devices. 2013 Adv Mind Body Med vol 27 vol 27 1 pages p 12-23 Cancer pagesp 12-23 Adv Mind Body Med, vol 27: 1, pagesp 12-23 Cancer: Cancer pain patients undergoing port placement 60bc (28 M/32F) cancer pain patients undergoing port placement (mean age = 54) Numerical Rating Scale (pain) State-Trait Anxiety Inventory (anxiety) Pain: Numerical Rating Scale; Mood: State-Trait Anxiety Inventory. 60 2-Acceptable CONTEXT: Despite major advances in cancer treatment, many patients undergo painful procedures during treatment and suffer debilitating side effects as well as report a decrease in quality of life (QOL). This problem is exacerbated for low-income, racial, and ethnic minorities with cancer. Minority cancer patients often enter care with larger tumors and with a more aggressive disease, increasing the risk of debilitating symptoms, such as pain and anxiety. Researchers have never assessed the feasibility and effectiveness of offering massage therapy for low-income, underserved cancer patients who are undergoing port insertion. OBJECTIVE: This study examined the feasibility of conducting a randomized, controlled trial (RCT) that would assess the use of massage therapy to reduce pain and anxiety in urban patients with cancer who undergo surgical placement of a vascular access device (port). The study also assessed the effectiveness of the intervention in reducing perioperative pain and anxiety. DESIGN: The research team conducted a 9-month RC T of 60 cancer patients undergoing port placement. The research team randomly assigned patients in a 2:1 ratio to usual care with massage therapy (intervention group) versus usual care with structured attention (control group). SETTING: The study took place at Boston Medical Center (BMC), which is an urban, tertiary-referral, safety-net hospital. PARTICIPANTS: Participants were cancer patients undergoing port placement. Sixty-seven percent were racial or ethnic minorities, and the majority were female and unemployed, with annual household incomes <$30 000 and publicly funded health insurance coverage. INTERVENTION: For the intervention, an expert panel developed a reproducible, standardized massage therapy intended for individuals undergoing surgical port insertion. Both groups received 20-minute interventions immediately pre- and postsurgery. The research team collected data on pain and anxiety before and after the preoperative and postoperative interventions as well as 1 day after the surgery. OUTCOME MEASURES: With respect to feasibility, the study examined (1) data about recruitment--time to complete enrollment and proportion of racial and ethnic minorities enrolled; (2) participants' retention; and (3) adherence to treatment allocation. The efficacy outcomes included measuring (1) participants' average pain level using an 11-point numerical rating scale (0 = no pain to 10 = worst possible pain) and (2) participants' situational anxiety using the State-Trait Anxiety Inventory (STAI). RESULTS: The research team assigned the 60 patients to the groups over 53 weeks. Sixty-seven percent of the participants were racial or ethnic minorities. A majority were female and unemployed, with annual household incomes <$30 000 and publicly funded health insurance coverage. Of the 40 patients allocated to massage therapy, the majority (n = 33) received both the pre- and postoperative interventions. Massage therapy participants had a statistically significant, greater reduction in anxiety after the first intervention compared with individuals receiving structured attention (-10.27 vs -5.21, P = .0037). CONCLUSIONS: Recruitment of low-income, minority patients into an RCT of massage therapy for perioperative pain and anxiety is feasible. Both massage therapy and structured attention proved beneficial for alleviating preoperative anxiety in cancer patients undergoing port placement Adolescent No, power not achieved No, not achieved Massage therapist Massage: 40 (18%); Structured Attention: 20 (30%). 40 (18%); 20 (30%). Massage: 2 x 20 mins, 2x, ND + ND; Structured Attention: 2 x 20 mins, 2x, ND + ND. 2 x 20 mins, 2x, ND + ND; 2 x 20 mins, 2x, ND + ND. No Numerical Rating Scale (pain): p = 0.0037 (between groups) post-op, prior to second intervention; p < 0.0001 (between groups) 1d post-op; State-Trait Anxiety Inventory (anxiety): p < 0.0001 (between groups) at all time points. Massage effective for: Pain, Mood. Authors do not report or mention anything about Aes http://www.ncbi.nlm.nih.gov/pubmed/?term=23341418
F1 11
Refid 2818
Quick Author Rosen, 2013-cancer
Author J. R. Rosen, R. Lawrence, M. Bouchard, G. Doros, P. Gardiner, R. Saper
Title Massage for perioperative pain and anxiety in placement of vascular access devices.
Publication Date 2013
Periodical Adv Mind Body Med
F8 vol
Volume 27
F10 vol 27
Issue 1
F12 pages
Page Start-End p 12-23
Group Cancer
F15 pagesp 12-23
Publication Data Adv Mind Body Med, vol 27: 1, pagesp 12-23
Condition Cancer: Cancer pain patients undergoing port placement
Condition (to hide) 60bc (28 M/32F) cancer pain patients undergoing port placement (mean age = 54)
Outcome Measures
cleaned up results Numerical Rating Scale (pain) State-Trait Anxiety Inventory (anxiety)
Outcome Measures_ Pain: Numerical Rating Scale; Mood: State-Trait Anxiety Inventory.
Total Participants 60
Quality Assignment (SIGN 50) 2-Acceptable
Abstract CONTEXT: Despite major advances in cancer treatment, many patients undergo painful procedures during treatment and suffer debilitating side effects as well as report a decrease in quality of life (QOL). This problem is exacerbated for low-income, racial, and ethnic minorities with cancer. Minority cancer patients often enter care with larger tumors and with a more aggressive disease, increasing the risk of debilitating symptoms, such as pain and anxiety. Researchers have never assessed the feasibility and effectiveness of offering massage therapy for low-income, underserved cancer patients who are undergoing port insertion. OBJECTIVE: This study examined the feasibility of conducting a randomized, controlled trial (RCT) that would assess the use of massage therapy to reduce pain and anxiety in urban patients with cancer who undergo surgical placement of a vascular access device (port). The study also assessed the effectiveness of the intervention in reducing perioperative pain and anxiety. DESIGN: The research team conducted a 9-month RC T of 60 cancer patients undergoing port placement. The research team randomly assigned patients in a 2:1 ratio to usual care with massage therapy (intervention group) versus usual care with structured attention (control group). SETTING: The study took place at Boston Medical Center (BMC), which is an urban, tertiary-referral, safety-net hospital. PARTICIPANTS: Participants were cancer patients undergoing port placement. Sixty-seven percent were racial or ethnic minorities, and the majority were female and unemployed, with annual household incomes <$30 000 and publicly funded health insurance coverage. INTERVENTION: For the intervention, an expert panel developed a reproducible, standardized massage therapy intended for individuals undergoing surgical port insertion. Both groups received 20-minute interventions immediately pre- and postsurgery. The research team collected data on pain and anxiety before and after the preoperative and postoperative interventions as well as 1 day after the surgery. OUTCOME MEASURES: With respect to feasibility, the study examined (1) data about recruitment--time to complete enrollment and proportion of racial and ethnic minorities enrolled; (2) participants' retention; and (3) adherence to treatment allocation. The efficacy outcomes included measuring (1) participants' average pain level using an 11-point numerical rating scale (0 = no pain to 10 = worst possible pain) and (2) participants' situational anxiety using the State-Trait Anxiety Inventory (STAI). RESULTS: The research team assigned the 60 patients to the groups over 53 weeks. Sixty-seven percent of the participants were racial or ethnic minorities. A majority were female and unemployed, with annual household incomes <$30 000 and publicly funded health insurance coverage. Of the 40 patients allocated to massage therapy, the majority (n = 33) received both the pre- and postoperative interventions. Massage therapy participants had a statistically significant, greater reduction in anxiety after the first intervention compared with individuals receiving structured attention (-10.27 vs -5.21, P = .0037). CONCLUSIONS: Recruitment of low-income, minority patients into an RCT of massage therapy for perioperative pain and anxiety is feasible. Both massage therapy and structured attention proved beneficial for alleviating preoperative anxiety in cancer patients undergoing port placement
Keywords Adolescent
Power No, power not achieved
Power1 No, not achieved
Provider Type Massage therapist
Intervention Description: Number Assigned (Dropout Rate) Massage: 40 (18%); Structured Attention: 20 (30%).
# Assigned (Dropout Rate)_ 40 (18%); 20 (30%).
double check # assign
Intervention Description: Dosages Massage: 2 x 20 mins, 2x, ND + ND; Structured Attention: 2 x 20 mins, 2x, ND + ND.
Intervention Description: Dosages1 2 x 20 mins, 2x, ND + ND; 2 x 20 mins, 2x, ND + ND.
*Meta-Analysis No
Relevant Results _ Numerical Rating Scale (pain): p = 0.0037 (between groups) post-op, prior to second intervention; p < 0.0001 (between groups) 1d post-op; State-Trait Anxiety Inventory (anxiety): p < 0.0001 (between groups) at all time points.
Conclusions Massage effective for: Pain, Mood.
Adverse Events Authors do not report or mention anything about Aes
PubMed Link http://www.ncbi.nlm.nih.gov/pubmed/?term=23341418
12 3058 Soden, 2004* K. Soden, K. Vincent, S. Craske, C. Lucas and S. Ashley A randomized controlled trial of aromatherapy massage in a hospice setting 2004 Palliative Medicine vol 18 vol 18 2 pages 87-92 Cancer pages 87-92 Palliative Medicine, vol 18: 2, pages 87-92 Cancer 42 (10 M/32 F) cancer patients (mean age = ND) Visual Analog Scale (pain) Modified Tursky Pain Descriptors (pain intensity) Verran and Snyder Halpern Sleep Scale (sleep quality) Hospital Anxiety and Depression Scale (anxiety and depression) Rotterdam Symptom Checklist (physical, psychological symptom distress, activity level, overall global life quality) Pain: Visual Analog Scale, Modified Tursky Pain Descriptors; Sleep: Verran and Snyder Halpern Sleep Scale; Mood: Hospital Anxiety and Depression Scale; Quality of Life: Rotterdam Symptom Checklist. 42 2-Acceptable Research suggests that patients with cancer particularly in the palliative care setting are increasingly using aromatherapy and massage. There is good evidence that these therapies may be helpful for anxiety reduction for short periods but few studies have looked at the longer term effects. This study was designed to compare the effects of four-week courses of aromatherapy massage and massage alone on physical and psychological symptoms in patients with advanced cancer. Forty-two patients were randomly allocated to receive weekly massages with lavender essential oil and an inert carrier oil (aromatherapy group) an inert carrier oil only (massage group) or no intervention. Outcome measures included a Visual Analogue Scale (VAS) of pain intensity the Verran and Snyder-Halpern (VSH) sleep scale the Hospital Anxiety and Depression (HAD) scale and the Rotterdam Symptom Checklist (RSCL). We were unable to demonstrate any significant long-term benefits of aromatherapy or massage in terms of improving pain control anxiety or quality of life. However sleep scores improved significantly in both the massage and the combined massage (aromatherapy and massage) groups. There were also statistically significant reductions in depression scores in the massage group. In this study of patients with advanced cancer the addition of lavender essential oil did not appear to increase the beneficial effects of massage. Our results do suggest however that patients with high levels of psychological distress respond best to these therapies. Aromatherapy No, power not achieved No Therapist (type not specified) Massage: 13 (ND); Massage + Aromatherapy (Active Control): 16 (ND); No Treatment: 13 (ND). 13 (ND); 16 (ND); 13 (ND). Massage: 4 x 30 mins, weekly, 4w + ND; Massage + Aromatherapy (Active Control): 4 x 30 mins, weekly, 4w + ND; No Treatment: ND x ND, weekly, 4w + ND. 4 x 30 mins, weekly, 4w + ND; 4 x 30 mins, weekly, 4w + ND; ND x ND, weekly, 4w + ND. Yes *Visual Analog Scale (pain): p = 0.03 (within groups) (Active Control) at treatment 2; p = Not Significant (within groups) (all groups) over time, Effect Size = -0.18, No Treatment, pre / post; Modified Tursky Pain Descriptors (pain intensity): p = Not Significant (within groups) (all groups) over time; Verran and Snyder Halpern Sleep Scale (sleep quality): p < 0.03 (within groups) (Active Control) at post; p = Not Significant (within groups) (all groups) at final assessment; Hospital Anxiety and Depression Scale (anxiety and depression): p < 0.05 (within groups) (Massage) at treatment 2 and 4; p = Not Significant (between groups) (all groups) over time; Rotterdam Symptom Checklist (physical, psychological symptom distress, activity level, overall global life quality): p = Not Significant (between groups) (all groups) over time. Massage effective for: Pain, Sleep, Mood. Authors do not report or mention anything about AEs http://www.ncbi.nlm.nih.gov/pubmed/?term=craske++A+randomized+controlled+trial+of+aromatherapy+massage+in+a+hospice+setting
F1 12
Refid 3058
Quick Author Soden, 2004*
Author K. Soden, K. Vincent, S. Craske, C. Lucas and S. Ashley
Title A randomized controlled trial of aromatherapy massage in a hospice setting
Publication Date 2004
Periodical Palliative Medicine
F8 vol
Volume 18
F10 vol 18
Issue 2
F12 pages
Page Start-End 87-92
Group Cancer
F15 pages 87-92
Publication Data Palliative Medicine, vol 18: 2, pages 87-92
Condition Cancer
Condition (to hide) 42 (10 M/32 F) cancer patients (mean age = ND)
Outcome Measures
cleaned up results Visual Analog Scale (pain) Modified Tursky Pain Descriptors (pain intensity) Verran and Snyder Halpern Sleep Scale (sleep quality) Hospital Anxiety and Depression Scale (anxiety and depression) Rotterdam Symptom Checklist (physical, psychological symptom distress, activity level, overall global life quality)
Outcome Measures_ Pain: Visual Analog Scale, Modified Tursky Pain Descriptors; Sleep: Verran and Snyder Halpern Sleep Scale; Mood: Hospital Anxiety and Depression Scale; Quality of Life: Rotterdam Symptom Checklist.
Total Participants 42
Quality Assignment (SIGN 50) 2-Acceptable
Abstract Research suggests that patients with cancer particularly in the palliative care setting are increasingly using aromatherapy and massage. There is good evidence that these therapies may be helpful for anxiety reduction for short periods but few studies have looked at the longer term effects. This study was designed to compare the effects of four-week courses of aromatherapy massage and massage alone on physical and psychological symptoms in patients with advanced cancer. Forty-two patients were randomly allocated to receive weekly massages with lavender essential oil and an inert carrier oil (aromatherapy group) an inert carrier oil only (massage group) or no intervention. Outcome measures included a Visual Analogue Scale (VAS) of pain intensity the Verran and Snyder-Halpern (VSH) sleep scale the Hospital Anxiety and Depression (HAD) scale and the Rotterdam Symptom Checklist (RSCL). We were unable to demonstrate any significant long-term benefits of aromatherapy or massage in terms of improving pain control anxiety or quality of life. However sleep scores improved significantly in both the massage and the combined massage (aromatherapy and massage) groups. There were also statistically significant reductions in depression scores in the massage group. In this study of patients with advanced cancer the addition of lavender essential oil did not appear to increase the beneficial effects of massage. Our results do suggest however that patients with high levels of psychological distress respond best to these therapies.
Keywords Aromatherapy
Power No, power not achieved
Power1 No
Provider Type Therapist (type not specified)
Intervention Description: Number Assigned (Dropout Rate) Massage: 13 (ND); Massage + Aromatherapy (Active Control): 16 (ND); No Treatment: 13 (ND).
# Assigned (Dropout Rate)_ 13 (ND); 16 (ND); 13 (ND).
double check # assign
Intervention Description: Dosages Massage: 4 x 30 mins, weekly, 4w + ND; Massage + Aromatherapy (Active Control): 4 x 30 mins, weekly, 4w + ND; No Treatment: ND x ND, weekly, 4w + ND.
Intervention Description: Dosages1 4 x 30 mins, weekly, 4w + ND; 4 x 30 mins, weekly, 4w + ND; ND x ND, weekly, 4w + ND.
*Meta-Analysis Yes
Relevant Results _ *Visual Analog Scale (pain): p = 0.03 (within groups) (Active Control) at treatment 2; p = Not Significant (within groups) (all groups) over time, Effect Size = -0.18, No Treatment, pre / post; Modified Tursky Pain Descriptors (pain intensity): p = Not Significant (within groups) (all groups) over time; Verran and Snyder Halpern Sleep Scale (sleep quality): p < 0.03 (within groups) (Active Control) at post; p = Not Significant (within groups) (all groups) at final assessment; Hospital Anxiety and Depression Scale (anxiety and depression): p < 0.05 (within groups) (Massage) at treatment 2 and 4; p = Not Significant (between groups) (all groups) over time; Rotterdam Symptom Checklist (physical, psychological symptom distress, activity level, overall global life quality): p = Not Significant (between groups) (all groups) over time.
Conclusions Massage effective for: Pain, Sleep, Mood.
Adverse Events Authors do not report or mention anything about AEs
PubMed Link http://www.ncbi.nlm.nih.gov/pubmed/?term=craske++A+randomized+controlled+trial+of+aromatherapy+massage+in+a+hospice+setting
13 3241 Toth, 2013* M. Toth, E. R. Marcantonio, R. B. Davis, T. Walton, J. R. Kahn and R. S. Phillips Massage Therapy for Patients with Metastatic Cancer: A Pilot Randomized Controlled Trial 2013 Journal of Alternative & Complementary Medicine vol 19 vol 19 7 pages 650-656 Cancer pages 650-656 Journal of Alternative & Complementary Medicine, vol 19: 7, pages 650-656 Cancer: Metastatic cancer patients 39c (7 M/32 F) metastatic cancer patients (mean age = 55.1) Brief Pain Inventory (pain severity and pain location subscales) Sleep (standardized subscale) Alertness (standardized subscale) Anxiety (standardized subscale) Physical well-being (Quality of Life) Psychological well-being (Quality of Life) McGill Quality of Life Questionnaire total (Quality of Life) Pain: Brief Pain Inventory; Sleep: Standardized sleep subscale; Standardized alertness subscale; Mood: Standardized anxiety subscale; Quality of Life: Physical well-being, Psychological well-being, McGill Quality of Life Questionnaire total. 39 2-Acceptable Objectives: The study objectives were to determine the feasibility and effects of providing therapeutic massage at home for patients with metastatic cancer. Design: This was a randomized controlled trial. Settings/location: Patients were enrolled at Oncology Clinics at a large urban academic medical center; massage therapy was provided in patients'' homes. Subjects: Subjects were patients with metastatic cancer. Interventions: There were three interventions: massage therapy no-touch intervention and usual care. Outcome measures: Primary outcomes were pain anxiety and alertness; secondary outcomes were quality of life and sleep. Results: In this study it was possible to provide interventions for all patients at home by professional massage therapists. The mean number of massage therapy sessions per patient was 2.8. A significant improvement was found in the quality of life of the patients who received massage therapy after 1-week follow-up which was not observed in either the No Touch control or the Usual Care control groups but the difference was not sustained at 1 month. There were trends toward improvement in pain and sleep of the patients after therapeutic massage but not in patients in the control groups. There were no serious adverse events related to the interventions. Conclusions: The study results showed that it is feasible to provide therapeutic massage at home for patients with advanced cancer and to randomize patients to a no-touch intervention. Providing therapeutic massage improves the quality of life at the end of life for patients and may be associated with further beneficial effects such as improvement in pain and sleep quality. Larger randomized controlled trials are needed to substantiate these findings. Massage No, power not achieved No Massage therapist Massage: 20 (0%); No Treatment: 10 (0%); Usual Care: 9 (0%). 20 (0%); 10 (0%); 9 (0%). Massage: 3 x 15-45 mins, 3x, 1w + ND; No Treatment: 3 x 15-45 mins, 3x, 1w + ND; Usual Care: ND x ND, ND, 1w + ND. 3 x 15-45 mins, 3x, 1w + ND; 3 x 15-45 mins, 3x, 1w + ND; ND x ND, ND, 1w + ND. Yes *Brief Pain Inventory (pain severity and pain location subscales): p = Not Significant (between groups) (Massage / No Treatment) from pre to post; p = Not Significant (between groups) (all groups) from baseline to 1w and baseline to 1 mos, Effect Size = 0.39, No Treatment, pre / post; Activities of daily living (standardized subscale): p = Not Described; Sleep (standardized subscale): p = Not Significant (between groups) (all groups) from baseline to 1w and baseline to 1 mos; Alertness (standardized subscale): p = Not Significant (between groups) (Massage / No Treatment) from pre to post; p = Not Significant (between groups) (all groups) from baseline to 1w and baseline to 1 mos; Anxiety (standardized subscale): p = Not Significant (between groups) (Massage / No Treatment) from pre to post; p = Not Significant (between groups) (all groups) from baseline to 1w and baseline to 1 mos; Physical well-being (Quality of Life): p = 0.0005 (between groups) (all groups) from baseline to 1w; p = Not Significant (between groups) (all groups) from baseline to 1 mos; Psychological well-being (Quality of Life): p = Not Significant (between groups) (all groups) from baseline to 1w and baseline to 1 mos; McGill Quality of Life Questionnaire total (Quality of Life): p = 0.03 (between groups) (all groups) from baseline to 1w; p = Not Significant (between groups) (all groups) from baseline to 1 mos. Massage effective for: Quality of Life. Authors report NO AEs occurred http://www.ncbi.nlm.nih.gov/pubmed/?term=rosen++Massage+Therapy+for+Patients+with+Metastatic+Cancer%3A+A+Pilot+Randomized+Controlled+Trial
F1 13
Refid 3241
Quick Author Toth, 2013*
Author M. Toth, E. R. Marcantonio, R. B. Davis, T. Walton, J. R. Kahn and R. S. Phillips
Title Massage Therapy for Patients with Metastatic Cancer: A Pilot Randomized Controlled Trial
Publication Date 2013
Periodical Journal of Alternative & Complementary Medicine
F8 vol
Volume 19
F10 vol 19
Issue 7
F12 pages
Page Start-End 650-656
Group Cancer
F15 pages 650-656
Publication Data Journal of Alternative & Complementary Medicine, vol 19: 7, pages 650-656
Condition Cancer: Metastatic cancer patients
Condition (to hide) 39c (7 M/32 F) metastatic cancer patients (mean age = 55.1)
Outcome Measures
cleaned up results Brief Pain Inventory (pain severity and pain location subscales) Sleep (standardized subscale) Alertness (standardized subscale) Anxiety (standardized subscale) Physical well-being (Quality of Life) Psychological well-being (Quality of Life) McGill Quality of Life Questionnaire total (Quality of Life)
Outcome Measures_ Pain: Brief Pain Inventory; Sleep: Standardized sleep subscale; Standardized alertness subscale; Mood: Standardized anxiety subscale; Quality of Life: Physical well-being, Psychological well-being, McGill Quality of Life Questionnaire total.
Total Participants 39
Quality Assignment (SIGN 50) 2-Acceptable
Abstract Objectives: The study objectives were to determine the feasibility and effects of providing therapeutic massage at home for patients with metastatic cancer. Design: This was a randomized controlled trial. Settings/location: Patients were enrolled at Oncology Clinics at a large urban academic medical center; massage therapy was provided in patients'' homes. Subjects: Subjects were patients with metastatic cancer. Interventions: There were three interventions: massage therapy no-touch intervention and usual care. Outcome measures: Primary outcomes were pain anxiety and alertness; secondary outcomes were quality of life and sleep. Results: In this study it was possible to provide interventions for all patients at home by professional massage therapists. The mean number of massage therapy sessions per patient was 2.8. A significant improvement was found in the quality of life of the patients who received massage therapy after 1-week follow-up which was not observed in either the No Touch control or the Usual Care control groups but the difference was not sustained at 1 month. There were trends toward improvement in pain and sleep of the patients after therapeutic massage but not in patients in the control groups. There were no serious adverse events related to the interventions. Conclusions: The study results showed that it is feasible to provide therapeutic massage at home for patients with advanced cancer and to randomize patients to a no-touch intervention. Providing therapeutic massage improves the quality of life at the end of life for patients and may be associated with further beneficial effects such as improvement in pain and sleep quality. Larger randomized controlled trials are needed to substantiate these findings.
Keywords Massage
Power No, power not achieved
Power1 No
Provider Type Massage therapist
Intervention Description: Number Assigned (Dropout Rate) Massage: 20 (0%); No Treatment: 10 (0%); Usual Care: 9 (0%).
# Assigned (Dropout Rate)_ 20 (0%); 10 (0%); 9 (0%).
double check # assign
Intervention Description: Dosages Massage: 3 x 15-45 mins, 3x, 1w + ND; No Treatment: 3 x 15-45 mins, 3x, 1w + ND; Usual Care: ND x ND, ND, 1w + ND.
Intervention Description: Dosages1 3 x 15-45 mins, 3x, 1w + ND; 3 x 15-45 mins, 3x, 1w + ND; ND x ND, ND, 1w + ND.
*Meta-Analysis Yes
Relevant Results _ *Brief Pain Inventory (pain severity and pain location subscales): p = Not Significant (between groups) (Massage / No Treatment) from pre to post; p = Not Significant (between groups) (all groups) from baseline to 1w and baseline to 1 mos, Effect Size = 0.39, No Treatment, pre / post; Activities of daily living (standardized subscale): p = Not Described; Sleep (standardized subscale): p = Not Significant (between groups) (all groups) from baseline to 1w and baseline to 1 mos; Alertness (standardized subscale): p = Not Significant (between groups) (Massage / No Treatment) from pre to post; p = Not Significant (between groups) (all groups) from baseline to 1w and baseline to 1 mos; Anxiety (standardized subscale): p = Not Significant (between groups) (Massage / No Treatment) from pre to post; p = Not Significant (between groups) (all groups) from baseline to 1w and baseline to 1 mos; Physical well-being (Quality of Life): p = 0.0005 (between groups) (all groups) from baseline to 1w; p = Not Significant (between groups) (all groups) from baseline to 1 mos; Psychological well-being (Quality of Life): p = Not Significant (between groups) (all groups) from baseline to 1w and baseline to 1 mos; McGill Quality of Life Questionnaire total (Quality of Life): p = 0.03 (between groups) (all groups) from baseline to 1w; p = Not Significant (between groups) (all groups) from baseline to 1 mos.
Conclusions Massage effective for: Quality of Life.
Adverse Events Authors report NO AEs occurred
PubMed Link http://www.ncbi.nlm.nih.gov/pubmed/?term=rosen++Massage+Therapy+for+Patients+with+Metastatic+Cancer%3A+A+Pilot+Randomized+Controlled+Trial
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